The second parable is more direct against the nation of Israel run by the Jewish religion.

Listen to how Adam Clark interprets the parable of the Vineyard owner in Matthew 21:33-45

Verse 33. There was a certain householder — Let us endeavour to find out a general and practical meaning for this parable. A householder – the Supreme Being. The family – the Jewish nation. The vineyard – the city of Jerusalem. The fence – the Divine protection. The wine-press – the law and sacrificial rites. The tower – the temple, in which the Divine presence was manifested. The husbandmen – the priests and doctors of the law. Went from home – entrusted the cultivation of the vineyard to the priests, c., with the utmost confidence as a man would do who had the most trusty servants, and was obliged to absent

himself from home for a certain time. Our Lord takes this parable from Isaiah 5:1, c. but whether our blessed Redeemer quote from the law, the prophets, or the rabbins, he reserves the liberty to himself to beautify the whole, and render it more pertinent.

Israel has always been compared to Gods own Vineyard, but the question is who is Israel? Those who follow the Vineyard owner not those who rebel against Him and His son! The true Israel are the chosen who have chosen to follow the Son Jesus.

These parable should be understood in context and they were directed a the Jewish leaders, the Phairisee who had all the people of Isreal in their grip.  We can see in this chapter that the people welcomed Jesus as their King singing Hossana and yet the Pharisees had them change in a few days to crying Crucify Him!!

Mat 21:38

But when the husbandmen saw the son, they said among themselves, This is the heir; come, let us kill him, and let us seize on his inheritance.

In this parable Jesus was obviously refering to Himself as the Son of God or the son of the Vineyard master.

Mat 21:41

They say unto him, He will miserably destroy those wicked men, and will let out his vineyard unto other husbandmen, which shall render him the fruits in their seasons.

Verse 41

“Verse Matthew 21:41. He will miserably destroy those wicked men — So, according to this evangelist, our Lord caused them to pass that sentence of destruction upon themselves which was literally executed about forty years after.” Adam Clark

“That he will miserably destroy those wicked men; it is destruction that is their doom. Kakous kakoµs apolesei-Malos male perdet. Let men never expect to do ill, and fare well. This was fulfilled upon the Jews, in that miserable destruction which was brought upon them by the Romans, and was completed about forty years after this; and unparalleled ruin,” Matthew Henry wrote this around 1710  years before the dispensational revelations hit hard in England and the USA in the mid 1800’s due to Darby and Scofield.

“He will destroy those wicked men miserably: The message of this parable is clear enough. With this answer, the chief priests and elders understood what the wicked servants deserved. Truly, those who rebel against their master this way deserve judgment.” David Guzak

Yet I have never heard the recent preachers tell or the Seige of Jerusalem and total destruction of the temple in 70AD  Why is this left in the memory hole today?

Mat 21:43

Therefore say I unto you, The kingdom of God shall be taken from you, and given to a nation bringing forth the fruits thereof.

“That the Jews shall be unchurched; The kingdom of God shall be taken from you. This turning out of the husbandmen speaks the same doom with that of dismantling the vineyard, and laying it common.” Matthew Henry

Note that when the Romans destroyed Jerusalem that the Temple and the Jewish religion was destroyed in 70AD. The Vineyard was dismantled by their own unbelief and they were cut out of the vine.  The fence and protection fell, as the walls of Jerusalem were breached and the Romans entered and plundered the Temple.

Isa 5:5

And now go to; I will tell you what I will do to my vineyard: I will take away the hedge thereof, and it shall be eaten up; and break down the wall thereof, and it shall be trodden down:

Isa 5:6

And I will lay it waste: it shall not be pruned, nor digged; but there shall come up briers and thorns: I will also command the clouds that they rain no rain upon it.

This was foreseen by the prophet and it came to pass on 70AD!

This is today generalized and taught as if it applies to every believe in Christ today. But no, it was specific to the nation of Israel follow the Pharisee who were about to throw the Vineyard owners son outside of their city and crucify Him!!

“He will destroy those wicked men miserably: The message of this parable is clear enough. With this answer, the chief priests and elders understood what the wicked servants deserved. Truly, those who rebel against their master this way deserve judgment.” David Guzaks comment

“verse Matthew 21:43. Therefore say I — Thus showing them, that to them alone the parable belonged. The kingdom of God shall be taken from you-the Gospel shall be taken from you, and given to the Gentiles, who will receive it, and bring forth fruit to the glory of God.” Adam Clark commented. It seems he was not afraid of offending Israel as a nation, but the Zionist Christians do.

Matthew 21:44.

“And whosoever shall fall on this stone shall be broken: but on whomsoever it shall fall, it will grind him to powder “

“Whosoever shall fall on this stone shall be broken, c. This is an allusion to the punishment of stoning among the Jews. The place of stoning was twice as high as a man while standing on this, one of the witnesses struck the culprit on the loins, so that he fell over this scaffold if he died by the stroke and fall, well; if not, the other witness threw a stone upon his heart, and despatched him. That stone thrown on the culprit was, in some cases, as much as two men could lift up. Tract Sanhed. and Bab. Gemara, and Lightfoot. See also the note on John 8:7. “Adam Clark

“Others, through malice, oppose Christ, and bid defiance to him in his estate of exaltation, when this Stone is advanced to the head of the corner; and on them it shall fall, for they pull it on their own heads, as the Jews did by that challenge, His blood be upon us and upon our children, and it will grind them to powder. The former seems to bespeak the sin and ruin of all unbelievers; this is the greater sin, and sorer ruin, of persecutors, that kick against the pricks, and persist in it” Matthew Henry

Mat 21:45

And when the chief priests and Pharisees had heard his parables, they perceived that he spake of them.

From this is it clear, that this was a parable directed specifically to the leaders of the nation of Isreal, those chief priests and Pharisees who wanted Jesus dead.